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Cake day: March 31st, 2025

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  • assuming that nuclear nonproliferation is gonna hold up indefinitely for any reason is some real fukuyama’s end of history shit

    let alone “because it’s Rational™ thing to do”, it’s only in rational interest of already-nuclear states to keep things this way. couple of states that could make a good point for having nuclear arsenal and having capability to manufacture it are effectively dissuaded from this by american diplomacy (mostly nuclear umbrella for allies and sanctions or fucking with their facilities for enemies). with demented pedo in chief and his idiot underlings trying their hardest to undo this all, i really wouldn’t be surprised if, say, south korea decides to get nuclear














  • i don’t think it would be so simple and i don’t think you can abstract neurons so hard, there are extrasynaptic receptors that react to concentrations of neurotransmitters outside synapses, and there are some neurotransmitters that leak out of synapses. thousands of leaking synapses can contribute to activation of some random receptor, or more than one this way. some other receptors are extrasynaptic by default and don’t really have synapses, neuropeptides work like this but not only these. for gasotransmitters, effectively there’s no concept of synapse. i don’t think you can abstract all neurotransmitters to some one chemical messenger either, there are different ones with different half-lives, different diffusion rates, different metabolites some of which work in completely different ways. (steroids, neuropeptides, gasotransmitters, whatever lipids go into cannabinoid system, it’s not just monoamines/glutamate/GABA/acetylcholine).

    some receptors take multiple inputs, there are NMDA receptors that really only fire when glutamate and glycine both bind to it, and only after AMPA receptor nearby opens up first. we already know these things are important in forming of memories so it’s probably a big deal. some of these receptors are ion channels, and some of these are important especially intracellular calcium