The world’s first human trial of a drug that can regenerate teeth will begin in a few months, less than a year on from news of its success in animals. This paves the way for the medicine to be commercially available as early as 2030.
The trial, which will take place at Kyoto University Hospital from September to August 2025, will treat 30 males aged 30-64 who are missing at least one molar. The intravenous treatment will be tested for its efficacy on human dentition, after it successfully grew new teeth in ferret and mouse models with no significant side effects.
“We want to do something to help those who are suffering from tooth loss or absence,” said lead researcher Katsu Takahashi, head of dentistry and oral surgery at Kitano Hospital. “While there has been no treatment to date providing a permanent cure, we feel that people’s expectations for tooth growth are high.”
Following this 11-month first stage, the researchers will then trial the drug on patients aged 2-7 who are missing at least four teeth due to congenital tooth deficiency, which is estimated to affect 1% of people. The team is recruiting for this Phase IIa trial now.
Do you disagree with what they actually said though?
Maybe everyone focuses on the negatives because we just did 5 straight years where it seems like if given the choice between two outcomes positive and negative, we’re living in the timeline where the negative thing always happens.
My point is that some bizarre monoculture has developed where people seem to be pathologically unable to accept that something good happened for a change, and to focus on the good thing. Virtually every comment finds some way to find some ultra-pessimistic take. The very best possible take is nearly always something like “wtf took them so long” or “OK, now do X”.
It should be okay - occasionally - to be happy that something good happened. We have the 98% of other posts out there to moan about and focus on the negative stuff.
It was bad on Reddit, but it seems even worse here.
It’s exhausting.
You make a valid point and I wish you’d stop being downvoted for it.
For those that might be downvoting their comment, just a reminder: downvotes are supposed to reflect the quality of a comment not your disagreement. A bad comment for example is something like “lol get rekt”
That being said…
I’m genuinely curious if there’s a place online where you find the discourse to be in anyway slanted toward the optimistic? I’d love to hang out there and after the Reddit exodus, for a while I personally genuinely tried to only have positive discourse here but I think the mood of the zeitgeist is exactly that: when the world seems shitty, everyone’s opinions seem shitty.