In October of this year, California banned BVO, along with other problematic food additives, including red dye No.
In a 2014 review of BVO, the FDA recognized the “unresolved safety questions” and designed rodent studies to address them, which were eventually run by the National Center for Toxicological Research (NCTR).
The rat experiments, published in 2022, used levels of BVO that mimicked dietary exposure of humans at the 15 ppm limit.
In feeding trials, researchers found abnormalities in the rats’ thyroids, alterations in their hormone signaling, and accumulation of brominated fatty acids in the heart, liver, and fat of all animals fed BVO.
“[W]e can no longer conclude that there is a reasonable certainty of no harm from the use of BVO as a stabilizer for flavoring oils in fruit-flavored beverages,” the FDA said in its proposal to revoke authorization.
In a separate statement, James Jones, the FDA’s Deputy Commissioner for Human Foods, noted that these types of safety reviews take time, but seemed to acknowledge the agency’s extremely slow process.
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In October of this year, California banned BVO, along with other problematic food additives, including red dye No.
In a 2014 review of BVO, the FDA recognized the “unresolved safety questions” and designed rodent studies to address them, which were eventually run by the National Center for Toxicological Research (NCTR).
The rat experiments, published in 2022, used levels of BVO that mimicked dietary exposure of humans at the 15 ppm limit.
In feeding trials, researchers found abnormalities in the rats’ thyroids, alterations in their hormone signaling, and accumulation of brominated fatty acids in the heart, liver, and fat of all animals fed BVO.
“[W]e can no longer conclude that there is a reasonable certainty of no harm from the use of BVO as a stabilizer for flavoring oils in fruit-flavored beverages,” the FDA said in its proposal to revoke authorization.
In a separate statement, James Jones, the FDA’s Deputy Commissioner for Human Foods, noted that these types of safety reviews take time, but seemed to acknowledge the agency’s extremely slow process.
The original article contains 550 words, the summary contains 171 words. Saved 69%. I’m a bot and I’m open source!