Is your heart medication dose dependent on weight?
It’s somewhat interesting, because the main heart meds are metabolic blockers (ramipril and bisoprolol, respectively an angiotensin-converting enzime inhibitor, and a beta1-selective blocker that inhibits cAMP phosphorylation), so they can only block certain metabolic paths and once that’s done, they can’t have more effect no matter the dose (they’re basically non-overdoseable).
But… at the same time, I had a diuretic added on (dapagliflozin) as part of a combined diabetes treatment, that used to work fine at the top weight, but at the bottom weight turned out to both reduce blood volume, impacting blood pressure, and lower blood sugar by too much, so that one had to go.
What do you credit for the 12kg regaining?
Reduction in stress (an extreme stress peak is what made me lose most of the weight), along with depression, and general despair due to a double back hernia that left me barely able to walk. I’m slightly better now after some physiotherapy, but still moving way less than before, so it’s anyone’s guess how it will go. It also made me switch to a worse diet, since I can’t stay up long enough to prepare healthier stuff.
It’s somewhat interesting, because the main heart meds are metabolic blockers (ramipril and bisoprolol, respectively an angiotensin-converting enzime inhibitor, and a beta1-selective blocker that inhibits cAMP phosphorylation), so they can only block certain metabolic paths and once that’s done, they can’t have more effect no matter the dose (they’re basically non-overdoseable).
But… at the same time, I had a diuretic added on (dapagliflozin) as part of a combined diabetes treatment, that used to work fine at the top weight, but at the bottom weight turned out to both reduce blood volume, impacting blood pressure, and lower blood sugar by too much, so that one had to go.
Reduction in stress (an extreme stress peak is what made me lose most of the weight), along with depression, and general despair due to a double back hernia that left me barely able to walk. I’m slightly better now after some physiotherapy, but still moving way less than before, so it’s anyone’s guess how it will go. It also made me switch to a worse diet, since I can’t stay up long enough to prepare healthier stuff.
Thanks for sharing, I don’t know why you are being downvoted or who is in this thread being a dick.