This can produce misleading or even false conclusions, and it can be hard to detect since it cannot usually be identified by examining the sample alone.
Studies examining how a particular treatment affects a particular health outcome often try to handle ascertainment bias by adjusting for “covariates,” things like education level or socioeconomic status, that could affect health outcomes independently of the treatment.
But Stefania Benonisdottir and Augustine Kong at Oxford’s Big Data Institute have just demonstrated that we can determine if genetic studies are biased using nothing but the genes of the participants.
Put differently, a bit of DNA that is common in the population will show up frequently in the study.
If a bit of DNA makes people more likely to enroll in genetic studies, it will be more common both in the overall data and among closely related family members.
So they checked the genetic sequences shared between first-degree relatives—either parents and children or siblings (but not twins)—in the UK Biobank.
The original article contains 410 words, the summary contains 164 words. Saved 60%. I’m a bot and I’m open source!
This is the best summary I could come up with:
This can produce misleading or even false conclusions, and it can be hard to detect since it cannot usually be identified by examining the sample alone.
Studies examining how a particular treatment affects a particular health outcome often try to handle ascertainment bias by adjusting for “covariates,” things like education level or socioeconomic status, that could affect health outcomes independently of the treatment.
But Stefania Benonisdottir and Augustine Kong at Oxford’s Big Data Institute have just demonstrated that we can determine if genetic studies are biased using nothing but the genes of the participants.
Put differently, a bit of DNA that is common in the population will show up frequently in the study.
If a bit of DNA makes people more likely to enroll in genetic studies, it will be more common both in the overall data and among closely related family members.
So they checked the genetic sequences shared between first-degree relatives—either parents and children or siblings (but not twins)—in the UK Biobank.
The original article contains 410 words, the summary contains 164 words. Saved 60%. I’m a bot and I’m open source!